New info on treating sepsis with vitamin C

[Joanna45]

DAVID GREENE, HOST:

Sepsis, or blood poisoning, is the nation's third-leading cause of death. Researchers now say they've developed a treatment that has been remarkably effective. Here's NPR's Richard Harris.

RICHARD HARRIS, BYLINE: One January day two years ago, Dr. Paul Marik was running the emergency room at a hospital in Norfolk, Va., when a desperately ill woman came in.

PAUL MARIK: We had this 48-year-old woman who previously had been reasonably healthy but came in with rapid, overwhelming sepsis.

HARRIS: Sepsis is a severe form of inflammation often triggered by an infection and frequently deadly.

MARIK: Her kidneys weren't working. Her lungs weren't working. And it was absolutely clear to me that she was going to die. In a situation like this, you start kind of thinking out of the box.

HARRIS: Marik had recently read a research report from scientists at Virginia Commonwealth University which found that intravenous vitamin C helped their patients with sepsis. He figured, what the heck? And he threw in some steroids and another vitamin for good measure.

MARIK: I was expecting that the next morning when I came to work, she would be dead. And really, when I walked in the next morning, I got the shock of my life.

HARRIS: The woman quickly recovered. Marik, at the Eastern Virginia Medical School, tried it in two more patients - same happy result. And 47 more - four of those patients died, he reports in the journal Chest. But they died from diseases that sent them to the hospital in the first place.

MARIK: The remarkable thing is not a single patient died from sepsis.

HARRIS: Especially remarkable considering that sepsis usually kills about a third of all patients who develop it. The study lacked the typical checks. There was no control group. Doctors and nurses knew who was getting the treatment. But the results were enough to change the way Marik treats sepsis.

MARIK: Now every single patient who is admitted, you know, without exception, gets it.

HARRIS: And by his informal tally, of 150 patients to date, only one has died from sepsis. I asked Dr. Craig Coopersmith at Emory University how big a deal this is.

CRAIG COOPERSMITH: If it turns out, on further studies, that this is true and we can validate it, then this will be an unbelievably huge deal. But right now, it should be viewed as a preliminary deal that needs to be validated.

HARRIS: There have been hundreds of studies of sepsis, many of them which seemed promising at first. But no drug has survived the more carefully controlled follow-up studies. Billions of dollars have been spent looking for a solution that might in fact end up being a mix of inexpensive ingredients.

Richard Harris, NPR News.

[Joanna45]

[ofonorow]

Thank you for the post. When I read and think about this, the idea that cortisol for IV production may have been deliberately sabotaged is not beyond the realm of possibility. The Marik protocol is a severe economic threat to the financing of most hospitals.

For those who don't know, I was in the hospital trying to evaluate my own cortisol requirements, when two bad vials of Solu-Cortef (hydrocortisone) were given to me. I think the odds are very small, unless this is a wide-spread problem.

Johnwen then discovered that this problem is wide-spread and has been reported to the FDA

Johnwen wrote:
HMMM! Seems your not alone!

On Apr, 10, 2018
4,156 people reported to have side effects when taking Solu-cortef.
Among them, 19 people (0.46%) have Hypoglycemia

https://www.ehealthme.com/ds/solu-cortef/hypoglycemia/

On Apr, 14, 2018
6,401 people reported to have side effects when taking drugs with ingredients of hydrocortisone sodium succinate.
Among them, 32 people (0.5%) have Hypoglycemia

https://www.ehealthme.com/is/hydrocorti ... oglycemia/

Added;
OWEN'
Where you given or taking metformin while you were in the hospital and they gave you this IV of Solu-Cortef?

[ofonorow]

How a mix of vitamins and steroids could kill sepsis: 6 things to know
https://www.beckershospitalreview.com/quality/how-a-mix-of-vitamins-and-steroids-could-kill-sepsis-6-things-to-know.html

The idea that new large studies are necessary is a delaying tactic. One bit of interesting news is to credit the idea to Alpha Folwer, MD.

Dr. Marik's treatment, a mixture of intravenous vitamin C, vitamin B1 and corticosteroids, was first developed by Alpha Fowler, MD, at Richmond-based Virginia Commonwealth University. Dr. Marik started using the combination treatment in 2016 and said it does not have consequential side effects. "At last count, over 700 patients have received the cocktail and, you know, the response is reproducible," Dr. Marik said.

And then there is the pesky problem that some, perhaps 50% of the hydrocortisone (Solu-Cortef) is faulty and probably won't work during these "large" trials.

[ofonorow]

A cure for an illness that kills thousands every year may be close
http://www.fox5atlanta.com/health/fox-medical-team/a-cure-for-an-illness-that-kills-thousands-every-year-may-be-close

This from Fox news.. the more news the better..

"It's incredibly frustrating. There have been over 100 clinical trials of sepsis, and none of them have been positive," says Dr. Coopersmith.

But Virginia critical care doctor Paul Marik believes this inexpensive I-V cocktail of vitamin C, hydrocortisone and thiamine may be able to stop sepsis. Dr. Marik says his protocol has cut the sepsis death rate in his hospital's ICU from "about 40%" to "maybe 1 or 2%." He believes the combination appears to cure severe sepsis, and septic shock.

"And, as outrageous as many people may think that statement is, we really believe it's true. We see it every day. And I this it has the potential to completely revolutionize the way we treat sepsis and septic shock," says Dr. Marik.

Still, many critical care doctors won't use Marik's Protocol because it hasn't been tested -- and proven to work -- in a large clinical trial. But Coopersmith has used it on a handful of sepsis patients, including a man he was convinced was dying,

[Joanna45]

The sad part is that if the patient is dying why not not give the vitamin C and hydrocortisone what would they possibly have to lose ..I just had a good friend die of sepsis..she went into the hospital to have abdominal surgery and got sepsis and never came home . She was 61 ..

[Joanna45]

[Saw]

There was another story out about 3 or 4 years ago, they were using Vitamin C and I think Olive leaf extract(?) for sepsis.
The results were very good but not as good as this one.
I can't seem to find it, maybe I have the olive leaf extract part wrong.
Anyone remember this?

[ofonorow]

no memory.
Researchers are trialing Marik's sepsis treatment in New Zealand. Bizarro.. The vitamin C treated folks get "conventional treatment" too, and it is double blind, meaning half the folks won't be getting vitamin C.

Vitamin C to be trialed as life-saving treatment for patients with sepsis
https://www.nzherald.co.nz/nz/news/arti ... d=12069636